“Extreme Endurance” explores the science behind human limits, contrasting real-world athletic feats with the often-exaggerated portrayals of survival in manga. The book delves into the physiological adaptations enabling extreme endurance and the psychological factors driving individuals beyond perceived limitations. Intriguingly, the cardiovascular system's role in oxygen delivery is vital, alongside metabolic processes and thermoregulation in maintaining body temperature under stress. By critically comparing manga depictions with scientific findings, the book aims to demystify endurance. The book presents information accessibly, building from fundamental principles and examining scenarios from ultra-marathon runners and free divers to survival in harsh environments. It analyzes the science involved, drawing from peer-reviewed articles and expert interviews, while also acknowledging manga's cultural impact. “Extreme Endurance” is structured in three parts: introducing key physiological concepts, examining specific examples, and synthesizing findings to discuss future research and ethical considerations. This unique approach provides a deeper appreciation for the body’s inherent capabilities and the representation of human potential in popular media. Readers gain insights into sports medicine, psychology, and cultural studies, enhancing a holistic understanding of endurance. It connects to sports medicine by examining injury prevention and psychology by exploring mental strategies used by athletes.