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GD1b localizes to neurons in the dorsal root ganglia, and antibodies directed against this ganglioside have been detected in some patients with idiopathic sensory neuronopathy.163 Further, rabbits immunized with purified GD1b develop ataxic sensory neuropathy, with loss of the cell bodies in the dorsal root ganglia and axonal degeneration of the dorsal column of the spinal cord without demyelination or an inflammatory infiltrate.

overlying skin. Once the calcinosis appears, treatment is very difficult. Colchicine, probenecid, warfarin, and phosphate buffers have been tried with limited success. Surgery may be performed, but the lesions may recur or worsen.